When I need to filter by two columns I just separate both conditions with & or *%20AND%20*. The result would look something like any of the two examples below:
* <rest of the URL>/my_view?$filter=column_1%20IN%20(1,2,3,4)&column_2=259
* <rest of the URL>/my_view?$filter=column_1%20IN%20(1,2,3,4)%20AND%column_2=259
Those are equivalent to a SQL WHERE condition such as:
WHERE (column_1 in (1, 2, 3, 4) AND column_2 = 259)
I would read the documentation on [parameters supported by the denodo restful web service and published rest web services](https://community.denodo.com/docs/html/browse/7.0/vdp/administration/restful_architecture/restful_web_service/input_parameters_of_the_restful_web_service#parameters-supported-by-the-denodo-restful-web-service-and-published-rest-web-services) to learn more about these features.
Hope this helps!